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GENERAL PEDIATRICS DRUG INFORMATION
acetaZOLAMIDE
Carbonic anhydrase inhibitor diuretic
Idiopathic intracranial hypertension
PO:
25-100 mg/kg/day (maximum: 2 000 mg/DAY) divided BID-TID
Excellent oral absorption, use IV only if PO is not possible. If using for metabolic alkalosis, first consider decreasing diuretic and adding or increasing potassium chloride supplements. Follow pH (for acid-base balance) and electrolytes carefully. Extend dosing interval in renal impairment
Administration: Administer with food (to decrease GI upset).
Availability: 250 mg tabs, compounded 25 mg/mL suspension, or 500 mg vial.
Pharmacology: Promotes urinary excretion of bicarbonate, sodium, potassium and water. Inhibition of carbonic anhydrase in the choroid plexus may decrease CSF production.
Updated: 12/21/2022
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