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GENERAL PEDIATRICS DRUG INFORMATION
Ampicillin
Penicillin derivative antibiotic
Meningitis or severe infections
IV:
Neonates (less than 1 month of age): 300-400 mg/kg/day divided Q6H
Infants and older children: 300-400 mg/kg/day (maximum: 3 g/dose; 12 g/DAY) divided Q6H
Q4H may be used in older children or adolescents.
Other infections
IV:
Neonates (less than 1 month of age): 100-200 mg/kg/day divided Q8H
Infants and older children: 100-200 mg/kg/day (maximum: 2 g/dose) divided Q6H
Extend dosing interval in renal impairment. Use amoxicillin if oral therapy is required. Typically used in uncomplicated community-acquired pneumonia, empiric early onset neonatal sepsis (along with gentamicin) and empiric treatment for febrile UTI in older children (along with tobramycin). Red rash may ocur.
Pharmacology: Broad spectrum penicillin with bactericidal activity – penetrates CSF. Inhibits penicillin-binding proteins, preventing peptidoglycan synthesis in bacterial cell walls – this causes cell lysis. Renally excreted, therefore dose adjusted in severe renal failure.
Updated: 12/21/2022
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