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GENERAL PEDIATRICS DRUG INFORMATION
Amoxicillin
Antibiotic
Acute otitis media - targeting Streptococcus pneumoniae (including empiric therapy)
PO:
80 - 90 mg/kg/DAY (usual maximum: 3 g/DAY) divided BID
or: 45 - 60 mg/kg/DAY (usual maximum: 3 g/DAY) divided TID
Community-acquired pneumonia - targeting Streptococcus pneumoniae (including empiric therapy)
PO:
Standard dose: 45 - 50 mg/kg/DAY (usual maximum: 3 g/DAY) divided TID
High dose: 80 - 90 mg/kg/DAY (usual maximum: 3 g/DAY) divided TID
Consider high dose for patients that are unimmunized, have risk factors for penicillin-resistant S. pneumoniae, or present with invasive or complicated infection.
Group A strep pharyngitis
PO:
50 mg/kg (maximum: 1 000 mg/dose) daily for 10 days
or: 25 mg/kg (maximum: 500 mg/dose) BID for 10 days
Prophylaxis in asplenia
PO:
10 mg/kg (maximum: 250 mg/dose) BID
Other infections
PO:
40 - 50 mg/kg/DAY divided TID
Pharmacology: Penicillin derivative antibiotic
Broad spectrum penicillin with bactericidal activity. Inhibits penicillin-binding proteins, preventing peptidoglycan synthesis in bacterial cell walls – this causes cell lysis.
Updated: 12/24/2025
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